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Home - Products - Angiogenesis - Bcl-2 - Desmorpholinyl Navitoclax-NH-Me

Desmorpholinyl Navitoclax-NH-Me

CAS No. 2365172-82-1

Desmorpholinyl Navitoclax-NH-Me ( Desmorpholinyl ABT-263-NH-Me )

Catalog No. M28241 CAS No. 2365172-82-1

Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Desmorpholinyl Navitoclax-NH-Me
  • Note
    Research use only, not for human use.
  • Brief Description
    Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 .
  • Description
    Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 .
  • Synonyms
    Desmorpholinyl ABT-263-NH-Me
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    AChR;BACE1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2365172-82-1
  • Formula Weight
    918.6
  • Molecular Formula
    C44H51ClF3N5O5S3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(CC1)CC(CN(CC2)CCN2c(cc2)ccc2C(NS(c(cc2)cc(S(C(F)(F)F)(=O)=O)c2N[C@H](CCNC)CSc2ccccc2)(=O)=O)=O)=C1c(cc1)ccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shrestha S, et al. Structure Related Inhibition of Enzyme Systems in Cholinesterases and BACE1 In Vitro by Naturally Occurring Naphthopyrone and Its Glycosides Isolated from Cassia obtusifolia. Molecules. 2017 Dec 28;23(1):69.
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